Aldose reductase gene polymorphisms and diabetic retinopathy susceptibility.

ABSTRACT:

Objective

Aldose reductase (ALR) is involved in diabetic microvascular damage via the polyol pathway. A recent meta-analysis found genetic variation in the ALR gene (AKR1B1) to be significantly associated with diabetic retinopathy (DR). We investigated the genetic association of AKR1B1 with DR.

Research design and methods

The study enrolled 909 individuals with diabetes. Participants were genotyped for an AKR1B1 (CA)n microsatellite and 14 tag single nucleotide polymorphisms, and ophthalmological assessment was performed.

Results

A total of 514 individuals were found to have DR. rs9640883 was significantly associated with DR (P = 0.0005). However, AKR1B1 variation was not independently associated with DR development after adjusting for relevant clinical parameters. rs

SUBMITTER: Abhary S 

PROVIDER: S-EPMC2909072 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature