Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation.

ABSTRACT:

Objective

To investigate whether apocynin protects the diaphragm from wasting and oxidative stress during mechanical ventilation (MV).

Design

Prospective, randomized, controlled study.

Setting

Research laboratory.

Subjects

Adult female Sprague-Dawley rats.

Interventions

Rats were randomly assigned to one of five experimental groups: 1) acutely anesthetized control, 2) spontaneous breathing control, 3) spontaneously breathing control with administration of the nicotinamide adenine dinucleotide phosphate oxidase inhibitor, apocynin, 4) mechanically ventilated, and 5) mechanically ventilated with apocynin.

Measurements and main results

Apocynin attenuated MV-induced diaphragmatic oxidative stress, contractile dysfunction, and type I, type IIa, and ty

SUBMITTER: McClung JM 

PROVIDER: S-EPMC2909189 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature