PTK6 regulates IGF-1-induced anchorage-independent survival.

ABSTRACT:

Background

Proteins that are required for anchorage-independent survival of tumor cells represent attractive targets for therapeutic intervention since this property is believed to be critical for survival of tumor cells displaced from their natural niches. Anchorage-independent survival is induced by growth factor receptor hyperactivation in many cell types. We aimed to identify molecules that critically regulate IGF-1-induced anchorage-independent survival.

Methods and results

We conducted a high-throughput siRNA screen and identified PTK6 as a critical component of IGF-1 receptor (IGF-1R)-induced anchorage-independent survival of mammary epithelial cells. PTK6 downregulation induces apoptosis of breast and ovarian cancer cells deprived of matrix attachment, whereas its ov

SUBMITTER: Irie HY 

PROVIDER: S-EPMC2909213 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature