Morphological and molecular characterization of developing vertebral fusions using a teleost model.

ABSTRACT:

Background

Spinal disorders are a major cause of disability for humans and an important health problem for intensively farmed animals. Experiments have shown that vertebral deformities present a complex but comparable etiology across species. However, the underlying molecular mechanisms involved in bone deformities are still far from understood. To further explicate the mechanisms involved, we have examined the fundamental aspects of bone metabolism and pathogenesis of vertebral fusions in Atlantic salmon (Salmo salar).

Results

Experimentally, juvenile salmon were subjected to hyperthermic conditions where more than 28% developed fused vertebral bodies. To characterize the fusion process we analyzed an intermediate and a terminal stage of the pathology by using x-ray, histol

SUBMITTER: Ytteborg E 

PROVIDER: S-EPMC2909226 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature