Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis.

ABSTRACT:

Purpose

To investigate the potential role of optical tomography in the near-infrared (NIR) spectrum with ultrasonographic (US) localization as a means of differentiating early-stage cancers from benign lesions of the breast.

Materials and methods

The protocol was approved by the institutional review boards and was HIPAA compliant; all participants signed an informed consent. One hundred seventy-eight consecutive women (mean age, 52 years; range, 21-89 years) who underwent US-guided biopsy were imaged with a hand-held probe consisting of a coregistered US transducer and an NIR imager. The lesion location provided by coregistered US was used to guide optical imaging. Light absorption was measured at two optical wavelengths. From this measurement, tumor angiogenesis was assesse

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC2909434 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature