Natural selection shapes nucleotide polymorphism across the genome of the nematode Caenorhabditis briggsae.

ABSTRACT: The combined actions of natural selection, mutation, and recombination forge the landscape of genetic variation across genomes. One frequently observed manifestation of these processes is a positive association between neutral genetic variation and local recombination rates. Two selective mechanisms and/or recombination-associated mutation (RAM) could generate this pattern, and the relative importance of these alternative possibilities remains unresolved generally. Here we quantify nucleotide differences within populations, between populations, and between species to test for genome-wide effects of selection and RAM in the partially selfing nematode Caenorhabditis briggsae. We find that nearly half of genome-wide variation in nucleotide polymorphism is explained by differences in local rec

SUBMITTER: Cutter AD 

PROVIDER: S-EPMC2909573 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature