Using DNA fingerprints to infer familial relationships within NHANES III households.

ABSTRACT: Developing, targeting, and evaluating genomic strategies for population-based disease prevention require population-based data. In response to this urgent need, genotyping has been conducted within the Third National Health and Nutrition Examination (NHANES III), the nationally-representative household-interview health survey in the U.S. However, before these genetic analyses can occur, family relationships within households must be accurately ascertained. Unfortunately, reported family relationships within NHANES III households based on questionnaire data are incomplete and inconclusive with regards to actual biological relatedness of family members. We inferred family relationships within households using DNA fingerprints (Identifiler(R)) that contain the DNA loci used by law enforcement

SUBMITTER: Katki HA 

PROVIDER: S-EPMC2909633 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature