Sudden infant death syndrome-associated mutations in the sodium channel beta subunits.

ABSTRACT:

Background

Approximately 10% of sudden infant death syndrome (SIDS) cases may stem from potentially lethal cardiac channelopathies, with approximately half of channelopathic SIDS involving the Na(V)1.5 cardiac sodium channel. Recently, Na(V) beta subunits have been implicated in various cardiac arrhythmias. Thus, the 4 genes encoding Na(V) beta subunits represent plausible candidate genes for SIDS.

Objective

This study sought to determine the spectrum, prevalence, and functional consequences of sodium channel beta-subunit mutations in a SIDS cohort.

Methods

In this institutional review board-approved study, mutational analysis of the 4 beta-subunit genes, SCN1B to 4B, was performed using polymerase chain reaction, denaturing high-performance liquid chromatography, and

SUBMITTER: Tan BH 

PROVIDER: S-EPMC2909680 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature