A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.

ABSTRACT: Crystal structures of A-form and B-form DNA duplexes containing 2'-S-methyl-uridines reveal that the modified residues adopt a RNA-like C3'-endo pucker, illustrating that the replacement of electronegative oxygen at the 2'-carbon of RNA by sulfur does not appear to fundamentally alter the conformational preference of the sugar in the oligonucleotide context and sterics trump stereoelectronics.

SUBMITTER: Pallan PS 

PROVIDER: S-EPMC2909737 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature