The Epithelial Sodium Channel alpha subunit (alpha ENaC) alternatively spliced form "b" in Dahl rats: What's next?

ABSTRACT:

Background

The amiloride-sensitive Epithelial Sodium Channel (ENaC) is critical in maintaining Na+ balance, extracellular fluid volume and long term blood pressure control. ENaC is composed of three main subunits alpha, beta, & gamma. While alpha ENaC is critical for channel functionality, beta & gamma ENaC maximize channel function. To date, there are four alternatively spliced forms of the alpha subunit of ENaC (alpha ENaC-a, -b, -c, & -d) that have been published in rats, in addition to the major alpha ENaC transcript. While alpha ENaC-a, -c & -d transcripts are low abundance transcripts compared to full-length alpha ENaC, alpha ENaC-b is a higher abundance and salt-sensitive transcript compared to full-length alpha ENaC.

Presentation of the hypothesis

alpha ENaC-b protei

SUBMITTER: Shehata MF 

PROVIDER: S-EPMC2909934 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature