Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells.

ABSTRACT:

Background

Viruses bind to specific cellular receptors in order to infect their hosts. The specific receptors a virus uses are important factors in determining host range, cellular tropism, and pathogenesis. For adenovirus, the existing model of entry requires two receptor interactions. First, the viral fiber protein binds Coxsackie and Adenovirus Receptor (CAR), its primary cellular receptor, which docks the virus to the cell surface. Next, viral penton base engages cellular integrins, coreceptors thought to be required exclusively for internalization and not contributing to binding. However, a number of studies reporting data which conflicts with this simple model have been published. These observations have led us to question the proposed two-step model for adenovirus infection.

SUBMITTER: Lyle C 

PROVIDER: S-EPMC2909962 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature