Necrosis related HIF-1alpha expression predicts prognosis in patients with endometrioid endometrial carcinoma.

ABSTRACT:

Background

Hypoxia inducible factor 1alpha (HIF-1alpha) plays an essential role in the adaptive response of cells to hypoxia and is associated with aggressive tumour behaviour. We have shown p27kip1, which is generally reduced in endometrial cancer, to be re-expressed in hypoxic regions. This possibly contributes to survival of cancer cells. The aim of this study was to evaluate the prognostic value of HIF-1alpha and p27kip expression in patients with endometrioid endometrial cancer.

Methods

Expression levels of HIF-1alpha, CAIX, Glut-1, and p27kip1 were analyzed by immunohistochemistry. Percentage of positive cells, staining pattern (perinecrotic, diffuse, or mixed) and presence of necrosis were noted.

Results

Necrosis was correlated with shortened disease free survi

SUBMITTER: Seeber LM 

PROVIDER: S-EPMC2909981 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature