Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults.

ABSTRACT:

Background

Recent experimental approaches have unraveled essential migratory and functional differences of monocyte subpopulations in mice. In order to possibly translate these findings into human physiology and pathophysiology, human monocyte subsets need to be carefully revisited in health and disease. In analogy to murine studies, we hypothesized that human monocyte subsets dynamically change during ageing, potentially influencing their functionality and contributing to immunosenescence.

Results

Circulating monocyte subsets, surface marker and chemokine receptor expression were analyzed in 181 healthy volunteers (median age 42, range 18-88). Unlike the unaffected total leukocyte or total monocyte counts, non-classical CD14+CD16+ monocytes significantly increased with age,

SUBMITTER: Seidler S 

PROVIDER: S-EPMC2910032 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature