Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.

ABSTRACT: In light of the relationship between immune system dysregulation and multiple myeloma (MM) risk, we investigated whether genetic variation in 92 immune function genes among 77 gene regions are associated with MM susceptibility in a population-based case-control study (108 cases and 482 controls) conducted among Caucasian women in Connecticut. Tagging single-nucleotide polymorphisms (SNPs; N = 870) were selected using a pairwise linkage-disequilibrium based algorithm. Odds ratios (ORs) and 95% confidence intervals (CIs) for SNP genotypes were estimated using unconditional logistic regression. Tests of association for gene regions were conducted using the minP test. We applied the false discovery rate (FDR) method to the minP test results as a means of controlling for multiple comparisons. T

SUBMITTER: Lee KM 

PROVIDER: S-EPMC2910184 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature