Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood.

ABSTRACT: Cellular aging is characterized by telomere shortening, which can lead to uncapping of chromosome ends (telomere dysfunction) and activation of DNA damage responses. There is some evidence that DNA damage accumulates during human aging and that lifestyle factors contribute to the accumulation of DNA damage. Recent studies have identified a set of serum markers that are induced by telomere dysfunction and DNA damage, and these markers showed an increased expression in blood during human aging. Here, we investigated the influence of lifestyle factors (such as exercise, smoking, body mass) on the aging-associated expression of serum markers of DNA damage (CRAMP, EF-1alpha, stathmin, n-acetyl-glucosaminidase and chitinase) in comparison with other described markers of cellular aging (p16(INK4a

SUBMITTER: Song Z 

PROVIDER: S-EPMC2910221 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature