Lecithin: cholesterol acyltransferase--from biochemistry to role in cardiovascular disease.

ABSTRACT:

Purpose of review

We discuss the latest findings on the biochemistry of lecithin : cholesterol acyltransferase (LCAT), the effect of LCAT on atherosclerosis, clinical features of LCAT deficiency, and the impact of LCAT on cardiovascular disease from human studies.

Recent findings

Although there has been much recent progress in the biochemistry of LCAT and its effect on high-density lipoprotein metabolism, its role in the pathogenesis of atherosclerosis is still not fully understood. Studies from various animal models have revealed a complex interaction between LCAT and atherosclerosis that may be modified by diet and by other proteins that modify lipoproteins. Furthermore, the ability of LCAT to lower apoB appears to be the best way to predict its effect on atherosclerosis i

SUBMITTER: Rousset X 

PROVIDER: S-EPMC2910390 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature