VEGF-A165b is cytoprotective and antiangiogenic in the retina.

ABSTRACT:

Purpose

A number of key ocular diseases, including diabetic retinopathy and age-related macular degeneration, are characterized by localized areas of epithelial or endothelial damage, which can ultimately result in the growth of fragile new blood vessels, vitreous hemorrhage, and retinal detachment. VEGF-A(165), the principal neovascular agent in ocular angiogenic conditions, is formed by proximal splice site selection in its terminal exon 8. Alternative splicing of this exon results in an antiangiogenic isoform, VEGF-A(165)b, which is downregulated in diabetic retinopathy. Here the authors investigate the antiangiogenic activity of VEGF(165)b and its effect on retinal epithelial and endothelial cell survival.

Methods

VEGF-A(165)b was injected intraocularly in a mouse model

SUBMITTER: Magnussen AL 

PROVIDER: S-EPMC2910648 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature