CFL1 expression levels as a prognostic and drug resistance marker in nonsmall cell lung cancer.

ABSTRACT:

Background

Nonsmall cell lung cancer (NSCLC) is the major determinant of overall cancer mortality worldwide. Despite progress in molecular research, current treatments offer limited benefits. Because NSCLC generates early metastasis, and this behavior requires great cell motility, herein the authors assessed the potential value of CFL1 gene (main member of the invasion/metastasis pathway) as a prognostic and predictive NSCLC biomarker.

Methods

Metadata analysis of tumor tissue microarray was applied to examine expression of CFL1 in archival lung cancer samples from 111 patients, and its clinicopathologic significance was investigated. The robustness of the finding was validated using another independent data set. Finally, the authors assayed in vitro the role of CFL1 levels

SUBMITTER: Castro MA 

PROVIDER: S-EPMC2910822 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature