Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults.

ABSTRACT:

Background & aims

Visceral adipose tissue (VAT) is an important risk factor for the metabolic complications associated with obesity. Therefore, a reduction in VAT is considered an important target of obesity therapy. We evaluated whether reducing VAT mass by surgical removal of the omentum improves insulin sensitivity and metabolic function in obese patients.

Methods

We conducted a 12-month randomized controlled trial to determine whether reducing VAT by omentectomy in 22 obese subjects increased their improvement following Roux-en-Y gastric bypass (RYGB) surgery in hepatic and skeletal muscle sensitivity to insulin study 1. Improvement was assessed by using the hyperinsulinemic-euglycemic clamp technique. We also performed a 3-month, longitudinal, single-arm study to determ

SUBMITTER: Fabbrini E 

PROVIDER: S-EPMC2910849 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature