Whole exome capture in solution with 3 Gbp of data.

ABSTRACT: We have developed a solution-based method for targeted DNA capture-sequencing that is directed to the complete human exome. Using this approach allows the discovery of greater than 95% of all expected heterozygous singe base variants, requires as little as 3 Gbp of raw sequence data and constitutes an effective tool for identifying rare coding alleles in large scale genomic studies.

SUBMITTER: Bainbridge MN 

PROVIDER: S-EPMC2911110 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature