Differential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD.

ABSTRACT: The canonical Wnt/beta-catenin (Wnt) pathway is a master transcriptional regulatory signaling pathway that controls numerous biological processes including proliferation and differentiation. As such, transcriptional activity of the Wnt pathway is tightly regulated and/or modulated by numerous proteins at the level of the membrane, cytosol and/or nucleus. In the nucleus, transcription of Wnt target genes by TCF/LEF-1 is repressed by the long Groucho/TLE co-repressor family. However, a truncated member of the Groucho/TLE family, amino terminal enhancer of Split (AES) can positively modulate TCF/LEF-1 activity by antagonizing long Groucho/TLE members in a dominant negative manner. We have previously shown the soluble intracellular domain of the LRP6 receptor, a receptor required for activatio

SUBMITTER: Beagle B 

PROVIDER: S-EPMC2911377 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature