Mouse lung contains endothelial progenitors with high capacity to form blood and lymphatic vessels.

ABSTRACT:

Background

Postnatal endothelial progenitor cells (EPCs) have been successfully isolated from whole bone marrow, blood and the walls of conduit vessels. They can, therefore, be classified into circulating and resident progenitor cells. The differentiation capacity of resident lung endothelial progenitor cells from mouse has not been evaluated.

Results

In an attempt to isolate differentiated mature endothelial cells from mouse lung we found that the lung contains EPCs with a high vasculogenic capacity and capability of de novo vasculogenesis for blood and lymph vessels.Mouse lung microvascular endothelial cells (MLMVECs) were isolated by selection of CD31+ cells. Whereas the majority of the CD31+ cells did not divide, some scattered cells started to proliferate giving rise to

SUBMITTER: Schniedermann J 

PROVIDER: S-EPMC2911414 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature