Protein docking by Rotation-Based Uniform Sampling (RotBUS) with fast computing of intermolecular contact distance and residue desolvation.

ABSTRACT:

Background

Protein-protein interactions are fundamental for the majority of cellular processes and their study is of enormous biotechnological and therapeutic interest. In recent years, a variety of computational approaches to the protein-protein docking problem have been reported, with encouraging results. Most of the currently available protein-protein docking algorithms are composed of two clearly defined parts: the sampling of the rotational and translational space of the interacting molecules, and the scoring and clustering of the resulting orientations. Although this kind of strategy has shown some of the most successful results in the CAPRI blind test http://www.ebi.ac.uk/msd-srv/capri, more efforts need to be applied. Thus, the sampling protocol should generate a pool of co

SUBMITTER: Solernou A 

PROVIDER: S-EPMC2911459 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature