Wireless pH-motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation.

ABSTRACT:

Background

Colon transit (CT) measurements are used in the management of significant constipation. The radiopaque marker (ROM) method provides limited information.

Methods

We proposed to validate wireless motility capsule (WMC), that measures pH, pressure and temperature, to ROM measurement of CT in patients with symptomatic constipation evaluated at multiple centers. Of 208 patients recruited, 158 eligible patients underwent simultaneous measurement of colonic transit time (CTT) using ROM (Metcalf method, cut off for delay >67 h), and WMC (cutoff for delay >59 h). The study was designed to demonstrate substantial equivalence, defined as diagnostic agreement >65% for patients who had normal or delayed ROM transit.

Key results

Fifty-nine of 157 patients had delayed ROM

SUBMITTER: Camilleri M 

PROVIDER: S-EPMC2911492 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature