Effect of exercise on oxidative stress: a 12-month randomized, controlled trial.

ABSTRACT:

Purpose

This study examined the effect of a yearlong exercise intervention on F2-isoprostane, a specific marker of lipid peroxidation and a general marker of oxidative stress.

Methods

In a randomized, controlled trial, 173 overweight or obese, postmenopausal, sedentary women were randomized either to an aerobic exercise intervention (60%-75% observed maximal HR) for > or =45 min.d-1, 5 d.wk-1 (n = 87), or to a stretching control group (n = 86), on an intent-to-treat basis. Baseline and 12-month measures included urinary F2-isoprostane, maximal O2 uptake, body weight, body fat percentage, waist circumference, and intra-abdominal fat surface area. Urine samples were available from 172 and 168 women at baseline and 12 months, respectively.

Results

During the 12-month stu

SUBMITTER: Campbell PT 

PROVIDER: S-EPMC2911514 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature