Chemoselective reductive cross-coupling of 1,5-diene-3-ols with alkynes: a facile entry to stereodefined skipped trienes.

ABSTRACT: A convergent synthesis of highly substituted and stereodefined skipped polyenes is described from the reductive cross-coupling of substituted 1,5-diene-3-ols with alkynes. The control of site selectivity in functionalization of the substituted diene is a central feature of this complex fragment union reaction.

SUBMITTER: Diez PS 

PROVIDER: S-EPMC2912438 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature