Testing haplotype-environment interactions using case-parent triads.

ABSTRACT:

Objective

Joint analysis of multiple SNP markers can be informative, but studying joint effects of haplotypes and environmental exposures is challenging. Population structure can involve both genes and exposures and a case-control study is susceptible to bias from either source of stratification. We propose a procedure that uses case-parent triad data and, though not fully robust, resists bias from population structure.

Methods

Our procedure assumes that haplotypes under study have no influence on propensity to exposure. Then, under a no-interaction null hypothesis (multiplicative scale), transmission of a causative haplotype from parents to affected offspring might show distortion from Mendelian proportions but should be independent of exposure. We used this insight to deve

SUBMITTER: Shi M 

PROVIDER: S-EPMC2912643 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature