Dual-functioning transcription factors in the developmental gene network of Drosophila melanogaster.

ABSTRACT:

Background

Quantitative models for transcriptional regulation have shown great promise for advancing our understanding of the biological mechanisms underlying gene regulation. However, all of the models to date assume a transcription factor (TF) to have either activating or repressing function towards all the genes it is regulating.

Results

In this paper we demonstrate, on the example of the developmental gene network in D. melanogaster, that the data-fit can be improved by up to 40% if the model is allowing certain TFs to have dual function, that is, acting as activator for some genes and as repressor for others. We demonstrate that the improvement is not due to additional flexibility in the model but rather derived from the data itself. We also found no evidence for the in

SUBMITTER: Bauer DC 

PROVIDER: S-EPMC2912886 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature