Ribavirin for Crimean-Congo hemorrhagic fever: systematic review and meta-analysis.

ABSTRACT:

Background

Crimean-Congo hemorrhagic fever epidemics often occur in areas where health services are limited, and result in high case fatality rates. Besides intensive care, ribavirin is often recommended. A solid evidence base for the use of this drug will help justify assuring access to the drug in areas where epidemics are common.

Methods

We carried out a systematic review of observational and experimental studies of people with suspected or confirmed Crimean-Congo hemorrhagic fever that included comparisons between patients given ribavirin and those not. We extracted data on mortality, hospital stay, and adverse events. Risk of bias was assessed using a standard checklist, and data were presented in meta-analytical graphs, stratified by study design, and GRADE tables pres

SUBMITTER: Soares-Weiser K 

PROVIDER: S-EPMC2912908 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature