Rise of oxyntomodulin in response to oral glucose after gastric bypass surgery in patients with type 2 diabetes.

ABSTRACT:

Context

The mechanisms by which Roux-en-Y gastric bypass surgery (GBP) results in sustained weight loss and remission of type 2 diabetes are not fully understood.

Objective

We hypothesized that the anorexic hormone oxyntomodulin (OXM) might contribute to the marked weight reduction and the rapid improvement in glucose metabolism observed in morbidly obese diabetic patients after GBP.

Methods

Twenty obese women with type 2 diabetes were studied before and 1 month after GBP (n=10) or after a diet-induced equivalent weight loss (n=10). Patients from both groups were matched for age, body weight, body mass index, and diabetes duration and control. OXM concentrations were measured during a 50-g oral glucose challenge before and after weight loss.

Results

At baseline

SUBMITTER: Laferrere B 

PROVIDER: S-EPMC2913033 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature