Reduced oxygenation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis.

ABSTRACT:

Context

Adipose tissue in obese individuals is characterized by reduced capillary density and reduced oxygenation.

Objective

Our objective was to test whether hypoxia is associated with reduced antilipolytic effect of insulin.

Participants, design, and setting

Twenty-one lean and obese individuals participated in this cross-sectional study at a university-based clinical research center.

Intervention

In all subjects, in situ adipose tissue (AT) oxygenation [AT oxygen partial pressure (ATpO2)] was measured with a Clark electrode, insulin sensitivity as well as basal and insulin-suppressed lipolysis (continuous infusion of (2H5)glycerol) were measured during a euglycemic-hyperinsulinemic clamp, and abdominal sc AT biopsies were collected to assess fat cell size (C

SUBMITTER: Pasarica M 

PROVIDER: S-EPMC2913036 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature