Runs of homozygosity identify a recessive locus 12q21.31 for human adult height.

ABSTRACT:

Background

Runs of homozygosity (ROHs) have recently been proposed to have potential recessive significance for complex traits. Human adult height is a classic complex trait with heritability estimated up to 90%, and recessive loci that contribute to adult height variation have been identified.

Methods

Using the Affymetrix 500K array set, we performed a genome-wide ROHs analysis to identify genetic loci for adult height in a discovery sample including 998 unrelated Caucasian subjects from the midwest United States. For the significant ROHs identified, we replicated these findings in a family-based sample of 8385 Caucasian subjects from the Framingham Heart Study (FHS).

Results

Our results revealed one ROH, located in 12q21.31, that had a strong association with adult

SUBMITTER: Yang TL 

PROVIDER: S-EPMC2913044 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature