Lung function and respiratory symptoms at 11 years in children born extremely preterm: the EPICure study.

ABSTRACT:

Rationale

The long-term respiratory sequelae of infants born extremely preterm (EP) and now graduating from neonatal intensive care remains uncertain.

Objectives

To assess the degree of respiratory morbidity and functional impairment at 11 years in children born EP (i.e., at or less than 25 completed weeks of gestation) in relation to neonatal determinants and current clinical status.

Methods

Pre- and postbronchodilator spirometry were undertaken at school in children born EP and classroom control subjects. Physical examination and respiratory health questionnaires were completed. Multivariable regression was used to estimate the predictive power of potential determinants of lung function.

Measurements and main results

Spirometry was obtained in 182 of 219 chil

SUBMITTER: Fawke J 

PROVIDER: S-EPMC2913237 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature