Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study.

ABSTRACT:

Rationale

Although obstructive sleep apnea is associated with physiological perturbations that increase risk of hypertension and are proatherogenic, it is uncertain whether sleep apnea is associated with increased stroke risk in the general population.

Objectives

To quantify the incidence of ischemic stroke with sleep apnea in a community-based sample of men and women across a wide range of sleep apnea.

Methods

Baseline polysomnography was performed between 1995 and 1998 in a longitudinal cohort study. The primary exposure was the obstructive apnea-hypopnea index (OAHI) and outcome was incident ischemic stroke.

Measurements and main results

A total of 5,422 participants without a history of stroke at the baseline examination and untreated for sleep apnea were f

SUBMITTER: Redline S 

PROVIDER: S-EPMC2913239 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature