Assessment and validation of the CAESAR predictive model for bioconcentration factor (BCF) in fish.

ABSTRACT:

Background

Bioconcentration factor (BCF) describes the behaviour of a chemical in terms of its likelihood of concentrating in organisms in the environment. It is a fundamental property in recent regulations, such as the European Community Regulation on chemicals and their safe use or the Globally Harmonized System for classification, labelling and packaging. These new regulations consider the possibility of reducing or waiving animal tests using alternative methods, such as in silico methods. This study assessed and validated the CAESAR predictive model for BCF in fish.

Results

To validate the model, new experimental data were collected and used to create an external set, as a second validation set (a first validation exercise had been done just after model development). The

SUBMITTER: Lombardo A 

PROVIDER: S-EPMC2913328 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature