An open source multistep model to predict mutagenicity from statistical analysis and relevant structural alerts.

ABSTRACT:

Background

Mutagenicity is the capability of a substance to cause genetic mutations. This property is of high public concern because it has a close relationship with carcinogenicity and potentially with reproductive toxicity. Experimentally, mutagenicity can be assessed by the Ames test on Salmonella with an estimated experimental reproducibility of 85%; this intrinsic limitation of the in vitro test, along with the need for faster and cheaper alternatives, opens the road to other types of assessment methods, such as in silico structure-activity prediction models.A widely used method checks for the presence of known structural alerts for mutagenicity. However the presence of such alerts alone is not a definitive method to prove the mutagenicity of a compound towards Salmonella, sin

SUBMITTER: Ferrari T 

PROVIDER: S-EPMC2913329 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature