S100A6 overexpression is associated with poor prognosis and is epigenetically up-regulated in gastric cancer.

ABSTRACT: S100A6 has been implicated in a variety of biological functions as well as tumorigenesis. In this study, we investigated the expression status of S100A6 in relation to the clinicopathological features and prognosis of patients with gastric cancer and further explored a possible association of its expression with epigenetic regulation. S100A6 expression was remarkably increased in 67.5% of gastric cancer tissues as compared with matched noncancerous tissues. Statistical analysis demonstrated a clear correlation between high S100A6 expression and various clinicopathological features, such as depth of wall invasion, positive lymph node involvement, liver metastasis, vascular invasion, and tumor-node metastasis stage (P < 0.05 in all cases), as well as revealed that S100A6 is an independent pr

SUBMITTER: Wang XH 

PROVIDER: S-EPMC2913363 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature