Identifying potential survival strategies of HIV-1 through virus-host protein interaction networks.

ABSTRACT:

Background

The National Institute of Allergy and Infectious Diseases has launched the HIV-1 Human Protein Interaction Database in an effort to catalogue all published interactions between HIV-1 and human proteins. In order to systematically investigate these interactions functionally and dynamically, we have constructed an HIV-1 human protein interaction network. This network was analyzed for important proteins and processes that are specific for the HIV life-cycle. In order to expose viral strategies, network motif analysis was carried out showing reoccurring patterns in virus-host dynamics.

Results

Our analyses show that human proteins interacting with HIV form a densely connected and central sub-network within the total human protein interaction network. The evaluation of

SUBMITTER: van Dijk D 

PROVIDER: S-EPMC2913931 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature