Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees.

ABSTRACT:

Background

Autism Spectrum Disorders (ASD) are phenotypically heterogeneous, characterized by impairments in the development of communication and social behaviour and the presence of repetitive behaviour and restricted interests. Dissecting the genetic complexity of ASD may require phenotypic data reflecting more detail than is offered by a categorical clinical diagnosis. Such data are available from the Social Responsiveness Scale (SRS) which is a continuous, quantitative measure of social ability giving scores that range from significant impairment to above average ability.

Methods

We present genome-wide results for 64 multiplex and extended families ranging from two to nine generations. SRS scores were available from 518 genotyped pedigree subjects, including affected and

SUBMITTER: Coon H 

PROVIDER: S-EPMC2913945 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature