Low levels of ATM in breast cancer patients with clinical radiosensitivity.

ABSTRACT:

Background and purpose

Adjuvant radiotherapy for cancer can result in severe adverse side effects for normal tissues. In this respect, individuals with anomalies of the ATM (ataxia telangiectasia) protein/gene are of particular interest as they may be at risk of both breast cancer and clinical radiosensitivity. The association of specific ATM gene mutations with these pathologies has been well documented, however, there is uncertainty regarding pathological thresholds for the ATM protein.

Results

Semi-quantitative immuno-blotting provided a reliable and reproducible method to compare levels of the ATM protein for a rare cohort of 20 cancer patients selected on the basis of their severe adverse normal tissue reactions to radiotherapy. We found that 4/12 (33%) of the breast ca

SUBMITTER: Fang Z 

PROVIDER: S-EPMC2914013 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature