Uncovering packaging features of co-regulated modules based on human protein interaction and transcriptional regulatory networks.

ABSTRACT:

Background

Network co-regulated modules are believed to have the functionality of packaging multiple biological entities, and can thus be assumed to coordinate many biological functions in their network neighbouring regions.

Results

Here, we weighted edges of a human protein interaction network and a transcriptional regulatory network to construct an integrated network, and introduce a probabilistic model and a bipartite graph framework to exploit human co-regulated modules and uncover their specific features in packaging different biological entities (genes, protein complexes or metabolic pathways). Finally, we identified 96 human co-regulated modules based on this method, and evaluate its effectiveness by comparing it with four other methods.

Conclusions

Dysfunction

SUBMITTER: Chen L 

PROVIDER: S-EPMC2914056 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature