Novel insight into the function and regulation of alphaN-catenin by Snail2 during chick neural crest cell migration.

ABSTRACT: The neural crest is a transient population of migratory cells that differentiates to form a variety of cell types in the vertebrate embryo, including melanocytes, the craniofacial skeleton, and portions of the peripheral nervous system. These cells initially exist as adherent epithelial cells in the dorsal aspect of the neural tube and only later become migratory after an epithelial-to-mesenchymal transition (EMT). Snail2 plays a critical role in mediating chick neural crest cell EMT and migration due to its expression by both premigratory and migratory cranial neural crest cells and its ability to down-regulate intercellular junctions components. In an attempt to delineate the role of cellular junction components in the neural crest, we have identified the adherens junction molecule neura

SUBMITTER: Jhingory S 

PROVIDER: S-EPMC2914159 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature