MicroRNA evolution in a human transcription factor and microRNA regulatory network.

ABSTRACT:

Background

microRNAs (miRNAs) are important cellular components. The understanding of their evolution is of critical importance for the understanding of their function. Although some specific evolutionary rules of miRNAs have been revealed, the rules of miRNA evolution in cellular networks remain largely unexplored. According to knowledge from protein-coding genes, the investigations of gene evolution in the context of biological networks often generate valuable observations that cannot be obtained by traditional approaches.

Results

Here, we conducted the first systems-level analysis of miRNA evolution in a human transcription factor (TF)-miRNA regulatory network that describes the regulatory relations among TFs, miRNAs, and target genes. We found that the architectural stru

SUBMITTER: Qiu C 

PROVIDER: S-EPMC2914650 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature