Distant homologs of anti-apoptotic factor HAX1 encode parvalbumin-like calcium binding proteins.

ABSTRACT:

Background

Apoptosis is a highly ordered and orchestrated multiphase process controlled by the numerous cellular and extra-cellular signals, which executes the programmed cell death via release of cytochrome c alterations in calcium signaling, caspase-dependent limited proteolysis and DNA fragmentation. Besides the general modifiers of apoptosis, several tissue-specific regulators of this process were identified including HAX1 (HS-1 associated protein X-1) - an anti-apoptotic factor active in myeloid cells. Although HAX1 was the subject of various experimental studies, the mechanisms of its action and a functional link connected with the regulation of apoptosis still remains highly speculative.

Findings

Here we provide the data which suggests that HAX1 may act as a regulator

SUBMITTER: Kokoszynska K 

PROVIDER: S-EPMC2914655 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature