Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray.

ABSTRACT: Pancreatic cancer has a high mortality rate, which is generally related to the initial diagnosis coming at late stage disease combined with a lack of effective treatment options. Novel agents that selectively detect pancreatic cancer have potential for use in the molecular imaging of cancer, allowing for non-invasive determination of tumor therapeutic response and molecular characterization of the disease. Such agents may also be used for the targeted delivery of therapy to tumor cells while decreasing systemic effects. Using complementary assays of mRNA expression profiling to determine elevated expression in pancreatic cancer tissues relative to normal pancreas tissues, and validation of protein expression by immunohistochemistry on tissue microarray, we have identified cell-surface targ

SUBMITTER: Morse DL 

PROVIDER: S-EPMC2914681 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature