IL-33 is produced by mast cells and regulates IgE-dependent inflammation.

ABSTRACT:

Background

IL-33 is a recently characterized IL-1 family cytokine and found to be expressed in inflammatory diseases, including severe asthma and inflammatory bowl disease. Recombinant IL-33 has been shown to enhance Th2-associated immune responses and potently increase mast cell proliferation and cytokine production. While IL-33 is constitutively expressed in endothelial and epithelial cells, where it may function as a transcriptional regulator, cellular sources of IL-33 and its role in inflammation remain unclear.

Methodology/principal findings

Here, we identify mast cells as IL-33 producing cells. IgE/antigen activation of bone marrow-derived mast cells or a murine mast cell line (MC/9) significantly enhanced IL-33. Conversely, recombinant IL-33 directly activated mast ce

SUBMITTER: Hsu CL 

PROVIDER: S-EPMC2914748 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature