Screen and clean: a tool for identifying interactions in genome-wide association studies.

ABSTRACT: Epistasis could be an important source of risk for disease. How interacting loci might be discovered is an open question for genome-wide association studies (GWAS). Most researchers limit their statistical analyses to testing individual pairwise interactions (i.e., marginal tests for association). A more effective means of identifying important predictors is to fit models that include many predictors simultaneously (i.e., higher-dimensional models). We explore a procedure called screen and clean (SC) for identifying liability loci, including interactions, by using the lasso procedure, which is a model selection tool for high-dimensional regression. We approach the problem by using a varying dictionary consisting of terms to include in the model. In the first step the lasso dictionary inclu

SUBMITTER: Wu J 

PROVIDER: S-EPMC2915560 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature