Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach.

ABSTRACT:

Background

It is well established that estrogen increases endometrial cancer risk, whereas progesterone opposes the estrogen effects. The PROGINS allele of the progesterone receptor (PGR) gene reduces the function of PGR and has been associated with increased risk of the endometrioid type ovarian cancer. We investigated whether genetic variation in PGR is also associated with endometrial cancer risk using a haplotype-based approach.

Methods

We pooled data from two endometrial cancer case-control studies that were nested within two prospective cohorts, the Multiethnic Cohort Study and the California Teachers Study. Seventeen haplotype-tagging single nucleotide polymorphisms (SNPs) across four linkage disequilibrium (LD) blocks spanning the PGR locus were genotyped in 583 inci

SUBMITTER: Lee E 

PROVIDER: S-EPMC2915632 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature