Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample.

ABSTRACT: Neuronal nicotinic acetylcholine receptors are activated by both endogenous acetylcholine and exogenous nicotine, making sequence variations in these receptors likely candidates for association with tobacco phenotypes. Previous studies have found evidence for significant association between single nucleotide polymorphisms (SNPs) in the genomic region containing the CHRNA6 and CHRNB3 genes and tobacco behaviors. In this study, we provide support for an association between these genes and tobacco dependence in the National Youth Survey Family Study wave 10, a nationally representative sample of households. Eight SNPs in the CHRNA6 and CHRNB3 genomic region were genotyped in 1051 subjects, approximately half of whom are members of sibling pairs. Genetic association with DSM-IV dependence was

SUBMITTER: Hoft NR 

PROVIDER: S-EPMC2915837 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature