Monozygotic twins with polypoidal choroidal vasuculopathy.

ABSTRACT:

Purpose

To present the first findings in the set of monozygotic twins with polypoidal choroidopathy (PCV).

Methods

Sixty two-year old monozygotic twin sisters were studied. The concordances and discordances of the clinical features of the twins were determined. Genomic DNA was extracted and genotyped for three established PCV risk-associated single nucleotide polymorphisms, viz CFH I62V, CFH Y402H, and ARMS A69S.

Results

Both patients had hemorrhagic pigment epithelial detachments with orange lesions beneath the retinal pigment epithelium. Indocyanine green angiography showed pathognomonic choroidal vascular networks with polypoidal structures uniocularly in one twin and binocularly in the other twin. Both twins were treated with photodynamic therapy, retinal photocoa

SUBMITTER: Machida S 

PROVIDER: S-EPMC2915866 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature